One4Support supports Microsoft Vista. As with Windows XP all versions are supported, however for the HOME versions users need to be aware that only stand-alone systems are supported. Within LAN's or WAN's the Vista Business versions are required.

This support is available for RITM (Remote IT Management) and M-OBS (Managed Online Backup Services). For Anti-virus and Anti-spyware functionalities both the stand alone McAfee TOPS suite and the integrated Kaseya Enterprise Security support Vista.